Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ubiquitin specific peptidase 2
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 68 kDa
Uniprot: O75604
Gene id: 10869
Background: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53
TP53 ubiquitination and thus indirectly promotes p53
TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53
TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1
S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL
BMAL1(By similarity).
Field of research: Epigenetics, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:200-1:2000; IHC: 1:20-1:200;IF:1:10-1:100
Target: USP2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat