Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: tripartite motif-containing 24
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 117 kDa
Uniprot: O15164
Gene id: 8805
Background: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53
TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53
TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR
NR3C1, thyroid hormone receptor(TR) and ESR1. Modulates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes(By similarity).
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP
Dilution: WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500
Target: TRIM24
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat