Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: cadherin 1, type 1, E-cadherin (epithelial)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 130 kDa
Uniprot: P12830
Gene id: 999
Background: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and
or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Field of research: Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB
Dilution: WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
Target: CDH1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat