Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: casein kinase 2, alpha prime polypeptide
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 37 kDa
Uniprot: P19784
Gene id: 1459
Background: Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine
threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase Iå, I©, I∂ and Ie, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an å2∫2 or an åå'∫2 structure. The a catalytic subunit is stimulated by the ∫ regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
Field of research: Signal Transduction, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF
Dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Target: CSNK2A2
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat