Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: zinc finger E-box binding homeobox 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 210 kDa
Uniprot: P37275
Gene id: 6935
Background: Acts as a transcriptional repressor. Inhibits interleukin-2(IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition(EMT) by recruiting SMARCA4
BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box(5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IP,IHC
Dilution: WB: 1:500-1:5000; IP: 1:200-1:2000;IHC: 1:500-1:5000
Target: ZEB1
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat