Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: ubiquilin 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 71 kDa
Uniprot: Q9UMX0
Gene id:
Background: UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IHC, WB, IF
Dilution: WB: 1:200-1:1000; IF: 1:10-1:100; IHC: 1:20-1:200
Target: UBQLN1
Purification: Immunogen affinity purified
Reactivity: Human, Rat