Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: tumor necrosis factor(ligand) superfamily, member 13b
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 32 kDa, 45-52 kDa
Uniprot: Q9Y275
Gene id: 10673
Background: Cytokine that binds to TNFRSF13B
TACI and TNFRSF17
BCMA. TNFSF13
APRIL binds to the same 2 receptors. Together, they form a 2 ligands-2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor(BAFFR
BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG
IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
Field of research: Immunology, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: TNFSF13B
Purification: Immunogen affinity purified
Reactivity: Human, Mouse