Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: SNAP-associated protein
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 15-18 kDa
Uniprot: O95295
Gene id: 23557
Background: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor(PubMed:25898167).
Field of research: Neuroscience
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IF, WB, IHC, FC, IP
Dilution: WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Target: SNAPIN
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat