Host : Mouse
Clonality: Monoclonal
Clone: 1A7
Isotype: IgG1
Immunogen: SWI
SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 58 kDa
Uniprot: Q96GM5
Gene id: 6602
Background: Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from a stem
progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem
progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A
BAF53A and PHF10
BAF45A, are exchanged for homologous alternative ACTL6B
BAF53B and DPF1
BAF45B or DPF3
BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal
proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element(VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor(VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1
SMARCA4 chromatin-remodeling complex for transactivation.
Field of research: Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: SMARCD1
Purification: Protein A+G purification
Reactivity: Human