SMAD7 antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: SMAD family member 7
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 46 kDa
Uniprot: O15105
Gene id: 4092
Background: Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator(By similarity).
Field of research: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: SMAD7
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: SMAD family member 7
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 46 kDa
Uniprot: O15105
Gene id: 4092
Background: Antagonist of signaling by TGF-beta(transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta(Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator(By similarity).
Field of research: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB
Dilution: WB: 1:500-1:2000
Target: SMAD7
Purification: Immunogen affinity purified
Reactivity: Human, Mouse
Internal Reference:
LM-17845
Website URL:
/shop/lm-17845-smad7-antibody-100-ug-103766
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[LM-17845] SMAD7 antibody - 100 µg
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