Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: splicing factor proline
glutamine-rich (polypyrimidine tract binding protein associated)
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 115 kDa
Uniprot: P23246
Gene id: 6421
Background: SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.
Field of research: Neuroscience, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
Target: SFPQ
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat