Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: kinesin family member 7
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 150 kDa
Uniprot: Q2M1P5
Gene id: 374654
Background: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity).
Field of research: Cell Division and Proliferation, Developmental biology
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, IP, WB
Dilution: WB: 1:500-1:2000; IP: 1:500-1:1000
Target: KIF7
Purification: Immunogen affinity purified
Reactivity: Human