Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: heterogeneous nuclear ribonucleoprotein K
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 51 kDa
Uniprot: P61978
Gene id: 3190
Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53
TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53
TP53, playing a role in p21
CDKN1A and 14-3-3 sigma
SFN induction(By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21(lincRNA-p21), a non-coding RNA induced by p53
TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Field of research: Neuroscience, Signal Transduction, Metabolism, Epigenetics
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IF, FC
Dilution: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:10-1:100
Target: HNRNPK
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat